Published Research

Objective Tobacco use in both smokeless and smoked forms is a very common addiction in India, with high prevalence in northern India. The relationship between tobacco consumption and oral mucosal changes and ulceration is not well documented and studied in the literature. The aim of this study is to explore the extent of tobacco use and its relationship with the development of mouth ulcers. Methods Cross-sectional healthcampswere organizedthrough community outreach for a previously unscreened population in the Braj region in Uttar Pradesh, India. A total of 2053 individuals were screened for common health-related issues in 20 camps covering 4 districts.

Background: Head and neck cancer in Indian perspective predominantly relates to tobacco use. The present study explores the prevalence of oral ulcers and its association with addictions among the population of Uttar Pradesh and Rajasthan, India. Methodology: The screening method in early detection of head and neck cancer is broadly symptom based. 1399 subjects from Uttar Pradesh and Rajasthan were screened by trained personnel between April and June 2015. Results: Study findings showed, mouth ulcers and trismus were common symptoms and tobacco chewing and smoking were common addictions.

Neuro Surgery

The VA is classically described as originating as the first branch of the ipsilateral subclavian artery. The VA origin is variable and has been identified at the aortic arch, CCA, and ICA. The most common aberrant origin, where the left VA originates from the aortic arch, between the left CCA and left subclavian artery, occurs in 2.4% to 5.8% of cases. The VA arising from the carotid artery is an extremely uncommon variant.1 We describe a case of 45 year old male presented with Hemifacial spasm in which on digital substraction angiography we found aberrant origin of left vertebral artery from left common carotid artery.

Lab Medicine & Biochemistry

Roma Pahwa, Uma Kumar, Nibhriti Das. Modulation of PBMC-decay accelerating factor (PBMC-DAF)and cytokines in rheumatoid arthritis. Mol Cell Biochem (2016) 414:85–94. DOI.org/10.1007/s11010-016-2661-x Rheumatoid arthritis is a painful chronic systemic inflammatory disease that afflicts females at all ages in much higher proportions than the males . It is an auto immune disorder.Etiology not clear but suggests immune dysregulation. With the hypothesis thatcomponents and functioning of the immune system are interlinked and that there might be inappropriate modulation of the expression of the inflammatory and regulatory components of the immune system in RA, we targeted at exploring the activity of the proinflammatory complement proteins in the serum, expression of complement regulatory protein DAF , pro-and anti- inflammatory cytokines and their correlations in the leukocytes from the patients with RA and healthy human subjects.The study suggested that reduced expression of DAF effected by increased levels of pro-inflammatory cytokines contribute very significantly to the disease manifestations. Finding is novel to suggest significance of complement-cytokine axis in the progression of RA.

Internal Medicine

Acute undifferentiated febrile illness (AUFI) is considered to be a febrile illness of < 3 weeks duration without any localized symptoms and specific signs.1 A number of diseases were included in this category. Most of these illnesses have nonspecific symptoms and signs and it is difficult to differentiate among them clinically. A huge gap is existing in understanding of specific clinical characteristics and diagnostic lab parameters to identify a specific illness. Even a very astute physician faces a big diagnostic challenge while managing these illnesses. Local pattern of febrile illness in a specific geographical area influences the differential diagnosis and laboratory workup for AUFI.

Gastro

Sharma K, Sharma M, Narang S, Mani RK, Prakasam KR, Goyal J and Agrawal A. Post ERCP Pancreatitis: A Endoscopist’s Night Mare! An Insight with Literature Review.J Liver Res DisordTher 2016, 2(5): 00036. DOI.org/10.15406/jlrdt.2016.02.00036 Post ERCP pancreatitis is a serious complication of Endoscopic Retrograde CholangioPancreaticography that, at the minimum, prolongs hospital stay and, in rare cases, causes serious morbidity and death. The potential for risk reduction has therefore been the matter of extensive research. Rectal Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) were found to be appropriate for clinical use. Pancreatic Duct (PD) stent placement is currently considered the standard of care in high-risk cases.

Dr. RK Mani

Trained in prestigious institutions in India and the UK, he is widely regarded as a pioneer and opinion leader in his field. An academician, teacher and editor of repute, he has several original international contributions.

Biostatistics

Global Burden of Disease Cancer Collaboration and Awasthi A. Global, Regional, and National Cancer Incidence, Mortality,Years of Life Lost, Years Lived with Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015, A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol. 2016 Dec 3. DOI.org/10.1001/jamaoncol.2016.5688 Cancer is the second leading cause of death worldwide. Between 2005 and 2015, cancer cases increased by 33 percent, mostly due to population aging and growth plus changes in age-specific cancer rates.Globally, the chances of developing cancer during a lifetime were 1 in 3 for men and 1 in 4 for women.Prostate cancer was the most common cancer globally in men (1.6 million cases); tracheal, bronchus and lung (TBL) cancer was the leading cause of cancer deaths for men. In India head and neck cancer was most frequent cancer, caused due to tobacco chewing.Breast cancer was the most common cancer for women (2.4 million cases) and the leading cause of cancer deaths in women, same trend follows in India also. The most common childhood cancers were leukemia, other neoplasms, non-Hodgkin lymphoma, and brain and nervous system cancers.