Lab Medicine & Biochemistry

21 March, 2020

Lab Medicine & Biochemistry

Roma Pahwa, Uma Kumar, Nibhriti Das. Modulation of PBMC-decay accelerating factor (PBMC-DAF)and cytokines in rheumatoid arthritis. Mol Cell Biochem (2016) 414:85–94. DOI.org/10.1007/s11010-016-2661-xRheumatoid arthritis is a painful chronic systemic inflammatory disease that afflicts females at all ages in much higher proportions than the males . It is an auto immune disorder.Etiology not clear but suggests immune dysregulation. With the hypothesis thatcomponents and functioning of the immune system are interlinked and that there might be inappropriate modulation of the expression of the inflammatory and regulatory components of the immune system in RA, we targeted at exploring the activity of the proinflammatory complement proteins in the serum, expression of complement regulatory protein DAF , pro-and anti- inflammatory cytokines and their correlations in the leukocytes from the patients with RA and healthy human subjects.The study suggested that reduced expression of DAF effected by increased levels of pro-inflammatory cytokines contribute very significantly to the disease manifestations. Finding is novel to suggest significance of complement-cytokine axis in the progression of RA.

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